Quasispecies and recombination
نویسندگان
چکیده
منابع مشابه
Quasispecies and recombination.
Recombination is introduced into Eigen's theory of quasispecies evolution. Comparing numerical simulations of the rate equations in the non-recombining and recombining cases show that recombination has a strong effect on the error threshold and, for a wide range of mutation rates, gives rise to two stable fixed points in the dynamics. This bi-stability results in the existence of two error thre...
متن کاملQuasispecies theory for horizontal gene transfer and recombination.
We introduce a generalization of the parallel, or Crow-Kimura, and Eigen models of molecular evolution to represent the exchange of genetic information between individuals in a population. We study the effect of different schemes of genetic recombination on the steady-state mean fitness and distribution of individuals in the population, through an analytic field theoretic mapping. We investigat...
متن کاملProbabilistic Inference of Viral Quasispecies Subject to Recombination
RNA viruses exist in their hosts as populations of different but related strains. The virus population, often called quasispecies, is shaped by a combination of genetic change and natural selection. Genetic change is due to both point mutations and recombination events. We present a jumping hidden Markov model that describes the generation of viral quasispecies and a method to infer its paramet...
متن کاملPhase diagrams of quasispecies theory with recombination and horizontal gene transfer.
We consider how transfer of genetic information between individuals influences the phase diagram and mean fitness of both the Eigen and the parallel, or Crow-Kimura, models of evolution. In the absence of genetic transfer, these physical models of evolution consider the replication and point mutation of the genomes of independent individuals in a large population. A phase transition occurs, suc...
متن کاملThe E ects of Recombination on a Haploid Quasispecies Evolving on a Single-peak Fitness Landscape
In this paper we investigate the eeects of (uniform) recombination on the evolution of a haploid quasispecies on a single-peak \spike" tness landscape. It is found that at low mutation rates the long-term behaviour of the quasispecies exhibits one stable and one unstable equilibrium. At a critical mutation rate which we identify as an error threshold, the stable and unstable equilibria coalesce...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Theoretical Population Biology
سال: 2006
ISSN: 0040-5809
DOI: 10.1016/j.tpb.2006.08.002